研究業績

Nishihara, H., Toda, Y., Kuramoto, T., Kamohara, K., Goto, A., Hoshino, K., Okada, S., Kuraku, S., Okabe, M., and Ishimaru Y.
A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception.
Nat. Ecol. Evol. 8, 111-120, 2024.
[PubMed]
[研究紹介：脊椎動物が極めて多様な味覚を持つことを発見――旨味と甘味の味覚の起源に迫る――]

Uchida, K., Fujitani, M., Mizushige, T., Hayamizu, K., Hara, Y., Sawai, M., Utsunomiya, S., Uehigashi, R., Okada, S., and Kishida, T.
Dietary Alaska Pollack Protein Induces Acute Skeletal Muscle Hypertrophy in Rats, Regardless of Specific Amino Acid and Amino Acid Balance of Diet.
Nutraceuticals 3, 513-528, 2023.

Hamano, M., Ichinose, T., Yasuda, T., Ishijima, T., Okada, S., Abe, K., Tashiro, K., and Furuya, S.
Bioinformatics Analysis of the Molecular Networks Associated with the Amelioration of Aberrant Gene Expression by a Tyr–Trp Dipeptide in Brains Treated with the Amyloid-β Peptide.
Nutrients 15, 2731, 2023.
[PubMed]

Uchida, K., Fujitani, M., Mizushige, T., Kawabata, F., Hayamizu, K., Uozumi, K., Hara, Y., Sawai, M., Uehigashi, R., Okada, S., Goto-Inoue, N., Morisasa, M., and Kishida, T.
Dietary Alaska Pollack Protein Induces Acute and Sustainable, Skeletal Muscle Hypertrophy in Rats.
Nutrients 14, 547, 2022.
[PubMed]

Liyanage, S. G. G., Inoue, R., Fujitani, M., Ishijima, T., Shibutani, T., Abe, K., Kishida, T. and Okada, S.
Effects of soy isoflavones, resistant starch and Antibiotics on polycystic ovary syndrome (PCOS)-like features in letrozole-treated rats.
Nutrients 13, 3759, 2021.
[PubMed]

Okubo, S., Terauchi, K., Okada, S., Saito, Y., Yamaura, T., Misaka, T., Nakajima, K., Abe, K., and Asakura, T.
De novo transcriptome analysis and comparative expression profiling of genes associated with the taste-modifying protein neoculin in Curculigo latifolia and Curculigo capitulata fruits.
BMC Genomics 22, 347, 2021.
[PubMed]
[研究紹介：クルクリゴ果実の味覚修飾タンパク質(ネオクリン)は、進化がくれた甘い贈り物]

Takase, T., Toyoda, T., Kobayashi, N., Inoue, T., Ishijima, T., Abe, K., Kinoshita, H., Tsuchiya, Y., and Okada, S.
Dietary iso-α-acids prevent acetaldehyde-induced liver injury through Nrf2-mediated gene expression.
PLoS One 16, e0246327, 2021.
[PubMed]

Takagi T., Hayashi R., Nakai Y., Okada S., Miyashita R., Yamada M., Mihara Y., Mizushima K., Morita M., Uchiyama K., Naito Y., and Itoh Y.
Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men-A Randomized, Double-Blind Trial.
Nutrients 12, E2342, 2020.
[PubMed]

Ichinose, T., Murasawa, H., Ishijima, T., Okada, S., Abe, K., Matsumoto, S., Matsui, T., and Furuya, S.
Tyr-Trp administration facilitates brain norepinephrine metabolism and ameliorates a short-term memory deficit in a mouse model of Alzheimer’s disease.
PLoS One 15, e0232233, 2020.
[PubMed]

Abe, A., Tanaka, M., Yasuoka, A., Saito, Y., Okada, S., Mishina, M., Abe, K., Kimura, K., and Asakura, T.
Changes in Whole-Blood microRNA Profiles during the Onset and Treatment Process of Cerebral Infarction: A Human Study.
Int. J. Mol. Sci. 21, 3107, 2020.
[PubMed]

Kawakami, S., Ito, R., Maruki-Uchida, H., Kamei, A., Yasuoka, A., Toyoda, T., Ishijima, T., Nishimura, E., Morita, M., Sai, M., Abe, K., and Okada, S.
Intake of a Mixture of Sake Cake and Rice Malt Increases Mucin Levels and Changes in Intestinal Microbiota in Mice.
Nutrients 12, E449, 2020.
[PubMed]

Toyoda, T., Iida, K., Ishijima, T., Abe, K., Okada, S.*, and Nakai, Y.
A maple syrup extract alleviates liver injury in type 2 diabetic model mice.
Nutr. Res. 73, 93-101, 2020.
[PubMed]

Toyoda, T., Kamei, A., Ishijima, T., Abe, K., and Okada, S.*
A maple syrup extract alters lipid metabolism in obese type 2 diabetic model mice.
Nutr. Metab. 16, 84, 2019.
[PubMed]

Fujitani, M., Mizushige, T., Kawabata, F., Uozumi, K., Yasui, M., Hayamizu, K., Uchida, K., Okada, S., Keshab, B., and Kishida, T.
Dietary Alaska pollack protein improves skeletal muscle weight recovery after immobilization-induced atrophy in rats.
PLoS One 14, e0217917, 2019.
[PubMed]

Shimazu, K., Fukumitsu, S., Ishijima, T., Toyoda, T., Nakai, Y., Abe, K., Aida, K., Okada, S.*, and Hino, A.
The Anti-Arthritis Effect of Olive-Derived Maslinic Acid in Mice is Due to its Promotion of Tissue Formation and its Anti-Inflammatory Effects.
Mol. Nutr. Food Res. 63, e1800543, 2019.
[PubMed]

Izuchi, R., Ishijima, T., Okada, S., Abe K., and Nakai, Y.
Hepatic fatty acid biosynthesis in KK-Ay mice is modulated by administration of persimmon peel extract: a DNA microarray study.
Food Sci. Nutr. 6, 1657-1663, 2018.
[PubMed]

Kamei, A., Watanabe, Y., Shinozaki, F., Yasuoka, A., Shimada, K., Kondo, K., Ishijima, T., Toyoda, T., Arai, S., Kondo, T., and Abe, K.
Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high-fat diet.
Mol. Nutr. Food Res. 61, e1600477, 2017.
[PubMed]

Tometsuka, C., Koyama, Y. I., Ishijima, T., Toyoda, T., Teranishi, M., Takehana, K., Abe, K., and Nakai, Y.
Collagen peptide ingestion alters lipid metabolism-related gene expression and the unfolded protein response in mouse liver.
Br. J. Nutr. 117, 1-11, 2017.
[PubMed]

Soulika, M., Kaushik, A. L., Mathieu, B., Lourenco, R., Komisarczuk, A. Z., Romano, S. A., Jouary, A., Lardennois, A., Tissot, N., Okada, S., Abe, K., Becker, T. S., and Kapsimali, M.
Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs.
Development 143, 2012-2024, 2016.
[PubMed]

Chun, S., Bamba, T., Suyama, T., Ishijima, T., Fukusaki, E., Abe, K., and Nakai, Y.
A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis.
PLoS ONE 11, e0155386, 2016.
[PubMed]

Maruyama, R., Shimizu, M., Ishijima, T., Nakai, Y., Inoue, J., and Sato, R.
Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.
Biosci. Biotechnol. Biochem. 80, 1149-1154, 2016.
[PubMed]

Yoshimoto, J., Okada, S., Kishi, M., and Misaka, T.
Ulex Europaeus Agglutinin-1 Is a Reliable Taste Bud Marker for In Situ Hybridization Analyses.
J. Histochem. Cytochem. 64, 205-215, 2016.
[PubMed]

Yoshida, K., Ushida, Y., Ishijima, T., Suganuma, H., Inakuma, T., Yajima, N., Abe, K., and Nakai, Y.
Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury.
World J. Gastroenterol. 21, 10091-10103, 2015.
[PubMed]

Kamei, A., Watanabe, Y., Shinozaki, F., Yasuoka, A., Kondo, T., Ishijima, T., Toyoda, T., Arai, S., and Abe, K.
Administration of a maple syrup extract to mitigate their hepatic inflammation induced by a high-fat diet: a transcriptome analysis.
Biosci. Biotechnol. Biochem. 79, 1893-1897, 2015.
[PubMed]

Oba, C., Ito, K., Ichikawa, S., Morifuji, M., Nakai, Y., Ishijima, T., Abe, K., and Kawahata, K.
Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis.
Physiol. Genomics 47, 355-363, 2015.
[PubMed]

Tsuboi, H., Nakai, Y., Iizuka, M., Asashima, H., Hagiya, C., Tsuzuki, S., Hirota, T., Miki, H., Hagiwara, S., Kondo, Y., Tanaka, A., Moriyama, M., Matsumoto, I., Nakamura, S., Yoshihara, T., Abe, K., and Sumida, T.
DNA microarray analysis of labial salivary glands in IgG4-related disease: comparison with Sjogren’s syndrome.
Arthritis Rheumatol. 66, 2892-2899, 2014.
[PubMed]

Fukui, Y., Sasaki, E., Fuke, N., Nakai, Y., Ishijima, T., Abe, K., and Yajima, N.
Sequential gene expression profiling in the mouse spleen during 14 d feeding with Lactobacillus brevis KB290.
Br. J. Nutr. 1-10, 2014.
[PubMed]

Kikuchi, Y., Toyoda, T., Ishijima, T., Abe, K., Nakai, Y., and Fukudome, S. I.
Oral administration of the AYA strain of Lactobacillus plantarum modulates expression of immunity-related genes in the murine Peyer’s patch: a DNA microarray analysis.
Biosci. Biotechnol. Biochem. in press.
[PubMed]

Horiba, T., Katsukawa, M., Abe, K., and Nakai, Y.
Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells.
Biosci. Biotechnol. Biochem. in press.
[PubMed]

Honda, S., Kawamoto, S., Tanaka, H., Kishida, H., Kitagawa, M., Nakai, Y., Abe, K., and Hirata, D.
Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis.
Biosci. Biotechnol. Biochem. 78, 655-661, 2014.
[PubMed]

Kanda, A., Ishijima, T., Shinozaki, F., Nakayama, K., Fukasawa, T., Nakai, Y., Abe, K., Kawahata, K., and Ikegami, S.
Post-exercise impact of ingested whey protein hydrolysate on gene expression profiles in rat skeletal muscle: activation of extracellular signal-regulated kinase 1/2 and hypoxia-inducible factor-1alpha.
Br. J. Nutr. 1-12, 2014.
[PubMed]

Fukui, Y., Sasaki, E., Fuke, N., Nakai, Y., Ishijima, T., Abe, K., and Yajima, N.
Sequential gene expression profiling in the mouse spleen during 14 d feeding with Lactobacillus brevis KB290.
Br. J. Nutr. 1-10, 2014.
[PubMed]

Yao, R., Yasuoka, A., Kamei, A., Ushiama, S., Kitagawa, Y., Rogi, T., Shibata, H., Abe, K., and Misaka, T.
Nuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages.
PLoS ONE 9, e87142, 2014.
[PubMed]
［研究紹介］

Watanabe, S., Katsube, T., Hattori, H., Sato, H., Ishijima, T., Nakai, Y., Abe, K., and Sonomoto, K.
Effect of Lactobacillus brevis 119-2 isolated from Tsuda kabu red turnips on cholesterol levels in cholesterol-administered rats.
J. Biosci. Bioeng. 116, 45-51, 2013.
[PubMed]

Kamei, A., Watanabe, Y., Kondo, K., Okada, S., Shinozaki, F., Ishijima, T., Nakai, Y., Kondo, T., Arai, S., and Abe, K.
Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats.
PLoS ONE 8, e65732, 2013.
[PubMed]

Fukui, Y., Sasaki, E., Fuke, N., Nakai, Y., Ishijima, T., Abe, K., and Yajima, N.
Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis.
Br. J. Nutr. 110, 1617-1629, 2013.
[PubMed]

Suyama, T., Okada, S., Ishijima, T., Iida, K., Abe, K., and Nakai, Y.
High Phosphorus Diet-Induced Changes in NaPi-IIb Phosphate Transporter Expression in the Rat Kidney: DNA Microarray Analysis.
PLoS ONE 7, e29483, 2012.
[PubMed]

Watanabe, Y., Kamei, A., Shinozaki, F., Ishijima, T., Iida, K., Nakai, Y., Arai, S., and Abe, K.
Ingested maple syrup evokes a possible liver-protecting effect-physiologic and genomic investigations with rats.
Biosci. Biotechnol. Biochem. 75, 2408-2410, 2011.
[PubMed]

Katsube, T., Yamasaki, M., Shiwaku, K., Ishijima, T., Matsumoto, I., Abe, K., and Yamasaki, Y.
Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice.
J. Sci. Food Agric. 90, 2386-2392, 2010.
[PubMed]

Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y., and Abe, K.
Dietary iron-deficient anemia induces a variety of metabolic changes and even apoptosis in rat liver: a DNA microarray study.
Physiol. Genomics 42, 149-156, 2010.
[PubMed]

Nakamura, A., Fujiwara, S., Ishijima, T., Okada, S., Nakai, Y., Matsumoto, I., Misaka, T., and Abe, K.
Neuron differentiation-related genes are up-regulated in the hypothalamus of odorant-inhaling rats subjected to acute restraint stress.
J. Agric. Food Chem. 58, 7922-7929, 2010.
[PubMed]

Ushiama, S., Nakamura, T., Ishijima, T., Misaka, T., Abe, K., and Nakai, Y.
The hepatic genes for immunoproteasome are upregulated by refeeding after fasting in the rat.
Biosci. Biotechnol. Biochem. 74, 1320-1323, 2010.
[PubMed]

Aizawa, K., Matsumoto, T., Inakuma, T., Ishijima, T., Nakai, Y., Abe, K., and Amano, F.
Administration of Tomato and Paprika Beverages Modifies Hepatic Glucose and Lipid Metabolism in Mice: A DNA Microarray Analysis.
J. Agric. Food Chem. 57, 10964-10971, 2009.
[PubMed]

Abe, K., Okada, S., and Ishijima, T.
The activities of the ILSI Japan endowed chair, at the University of Tokyo, regarding functional food genomics.
Nutr Rev. 78(Supplement_3), 35-39, 2020.
[PubMed]

Okada, S.
The taste system of small fish species.
Biosci. Biotechnol. Biochem. 79, 1039-1043, 2015.
[PubMed]